SHC1 (SHC (Src homology 2 domain containing) transforming protein 1)

Targeting src Homology 2-Containing Inositol Phosphatase-1 (SHIP1)

25 MicroRNAs (miRNAs) are single stranded small RNA molecules that regulate various cellular 26 processes. miR-155 regulates various aspects of innate and adaptive immune response and plays 27 a key role in various viral infections and resulting neuroinflammation. In the present study, 28 evaluated the involvement of miR-155 in modulating Japanese Encephalitis Virus (JEV)29 induced neuroinflamm...

The role of the Src Homology-2 domain containing protein B (SHB) in b cells

This review will describe the SH2-domain signaling protein Src Homology-2 domain containing protein B (SHB) and its role in various physiological processes relating in particular to glucose homeostasis and b cell function. SHB operates downstream of several tyrosine kinase receptors and assembles signaling complexes in response to receptor activation by interacting with other signaling proteins...

The Src Homology 2 Domain-Containing Adapter Protein B (SHB) Regulates Mouse Oocyte Maturation

SHB (Src homology 2 domain-containing adapter protein B) is involved in receptor tyrosine kinase signaling. Mice deficient in the Shb gene have been found to exhibit a transmission ratio distortion with respect to inheritance of the Shb null allele among offspring and this phenomenon was linked to female gamete production. Consequently, we postulated that Shb plays a role for oocyte biology and...

src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation.

Th2 cells are generated from naive CD4 T cells upon T cell receptor (TCR) recognition of antigen and IL-4 stimulation and play crucial roles in humoral immunity against infectious microorganisms and the pathogenesis of allergic and autoimmune diseases. A tyrosine phosphatase, SHP-1, that contains src homology 2 (SH2) domains is recognized as a negative regulator for various intracellular signal...

A photoactivatable Src homology 2 (SH2) domain